Review Article Small RNAs in transcriptional gene silencing and genome defence. Danesh Moazed 1. Top. They further showed that the dsRNA synthesis activity is required for RNAi-mediated gene silencing. | Article | PubMed | ChemPort | Buker, S. M. et al. Two different Argonaute complexes are required for siRNA generation and heterochromatin assembly in fission yeast. Nature Struct. Mol.
- Review Article from The New England Journal of Medicine — Gene Silencing in Cancer in Association with Promoter Hypermethylation.
- Gene silencing is a general term used to describe the regulation of gene expression In particular, this term refers to the ability of a cell to prevent the expression of a certain gene Gene silencing can occur during either transcription or translation and is often used in research.
RNA Interference Review. RNA interference (RNAi) is one of the most exciting discoveries of the past decade in functional genomics. RNAi is rapidly becoming an important method for analyzing gene functions in eukaryotes and holds promise for the development of therapeutic gene silencing.
Gene Silencing Review Article Definition
Herman and Baylin (Nov. 20 issue) 1 provide an excellent review of gene silencing in cancer in association with promoter hypermethylation. However, some readers who are new to the field will be confused by the introductory section of their article — in particular, the authors' explanation of the term “epigenetic,” which suggests that this term describes “a heritable change in the pattern of gene expression.”.